A New Synthesis of a Potent Cancer Chemopreventive Agent, 13-Oxo-15,16-dinorlabda-8(17),11E-dien-19-oic Acid from trans-Communic Acid

Takahiro Katoh; Reiko Tanaka; Masatoshi Takeo; Kiyoharu Nishide; Manabu Node

doi:10.1248/cpb.50.1625

Notes

A New Synthesis of a Potent Cancer Chemopreventive Agent, 13-Oxo-15,16-dinorlabda-8(17),11E-dien-19-oic Acid from trans-Communic Acid

Takahiro Katoh, Reiko Tanaka, Masatoshi Takeo, Kiyoharu Nishide, Manabu Node

Author information

Keywords: trans-communic acid, Thuja standishii, chemical conversion, (−)-13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid

JOURNAL FREE ACCESS

2002 Volume 50 Issue 12 Pages 1625-1629

DOI https://doi.org/10.1248/cpb.50.1625

Details

Abstract

The first synthesis of a labdane diterpenoid, (−)-13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid [(−)-1a], isolated from the stem bark of Thuja standishii (GORD.) CARR., from the major component trans-communic acid (3a) is described.

Corresponding author

Register with J-STAGE for free!