Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata N<small>EES</small>

Fumihiro Nagashima; Masuo Kondoh; Toshinari Uematsu; Akiko Nishiyama; Sayaka Saito; Masao Sato; Yoshinori Asakawa

doi:10.1248/cpb.50.808

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Cytotoxic and Apoptosis-Inducing ent-Kaurane-Type Diterpenoids from the Japanese Liverwort Jungermannia truncata NEES

Fumihiro Nagashima, Masuo Kondoh, Toshinari Uematsu, Akiko Nishiyama, Sayaka Saito, Masao Sato, Yoshinori Asakawa

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Keywords: Jungermannia truncata, liverwort, gymnomitrane (=barbatane)-type, ent-kaurane-type, cytotoxic activity, apoptosis

JOURNAL FREE ACCESS

2002 Volume 50 Issue 6 Pages 808-813

DOI https://doi.org/10.1248/cpb.50.808

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Abstract

Five new ent-kaurane-type diterpenoids and a new gymnomitrane (=barbatane)-type sesquiterpenoid have been isolated from the Japanese liverwort Jungermannia truncata NEES, together with twelve previously known ent-kaurane-type diterpenoids. The structures of the new compounds were elucidated by two-dimensional (2D) NMR experiments and chemical reaction. Some of the isolated compounds showed cytotoxicity against human leukemia cell lines and induced apoptosis.

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