Lembehsterols A and B, Novel Sulfated Sterols Inhibiting Thymidine Phosphorylase, from the Marine Sponge Petrosia strongylata

Shunji Aoki; Yoshiharu Naka; Takuya Itoh; Tatsuhiko Furukawa; Rachmaniar Rachmat; Shin-ichi Akiyama; Motomasa Kobayashi

doi:10.1248/cpb.50.827

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Lembehsterols A and B, Novel Sulfated Sterols Inhibiting Thymidine Phosphorylase, from the Marine Sponge Petrosia strongylata

Shunji Aoki, Yoshiharu Naka, Takuya Itoh, Tatsuhiko Furukawa, Rachmaniar Rachmat, Shin-ichi Akiyama, Motomasa Kobayashi

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Keywords: lembehsterol, thymidine phosphorylase, angiogenesis, sulfated sterol, sponge

JOURNAL FREE ACCESS

2002 Volume 50 Issue 6 Pages 827-830

DOI https://doi.org/10.1248/cpb.50.827

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Abstract

Lembehsterols A (1) and B (2), two novel sulfated sterols, were isolated from the marine sponge Petrosia strongylata. Both sterols showed inhibitory activity against thymidine phosphorylase, which is an enzyme related to angiogenesis in solid tumors. The structures of these sulfated sterols were established on the basis of chemical and physicochemical evidence.

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