Elucidation of Solid-State Complexation in Ground Mixtures of Cholic Acid and Guest Compounds

Toshio Oguchi; Yuichi Tozuka; Takehisa Hanawa; Mayuko Mizutani; Nahomi Sasaki; Sontaya Limmatvapirat; Keiji Yamamoto

doi:10.1248/cpb.50.887

Regular Articles

Elucidation of Solid-State Complexation in Ground Mixtures of Cholic Acid and Guest Compounds

Toshio Oguchi, Yuichi Tozuka, Takehisa Hanawa, Mayuko Mizutani, Nahomi Sasaki, Sontaya Limmatvapirat, Keiji Yamamoto

著者情報

キーワード: complexation, cholic acid, grinding, inclusion compound, methyl p-hydroxybenzoate, ibuprofen

ジャーナルフリー

2002 年 50 巻 7 号 p. 887-891

DOI https://doi.org/10.1248/cpb.50.887

詳細

抄録

The solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA–MPB was 1 : 1 while that of CA–IBP was 2 : 1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules.

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