2002 Volume 50 Issue 7 Pages 900-903
By bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranoside (2) and pictogenin (3β,6β,16α,23-tetrahydroxyolean-12-ene-28-oic acid) 3-O-α-L-arabinopyranoside (3), respectively, by spectral analysis and by chemical degradation. Kalopanaxsaponin A and pictoside A showed significant anti-inflammatory activity at the oral doses of 50 mg/kg.
