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Volume 50, Issue 7
Displaying 1-26 of 26 articles from this issue
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Regular Articles
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Toshio Oguchi, Yuichi Tozuka, Takehisa Hanawa, Mayuko Mizutani, Nahomi ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 887-891
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe solid-state complexation between cholic acid (CA) and either methyl p-hydroxybenzoate (MPB) or ibuprofen (IBP) was investigated. Powder X-ray diffractometry, IR spectroscopy and thermal analysis suggested the complex formation between CA and MPB as well as between CA and IBP by co-grinding method. The stoichiometry of CA–MPB was 1 : 1 while that of CA–IBP was 2 : 1, reflecting the effect of guest size on complex formation. The guest compounds were assumed to be included in the channel of complexes formed by hydrogen bonds among CA molecules.View full abstractDownload PDF (66K) -
Chellan Vijaya Raghavan, Chithambaram Muthulingam, Joseph Amaladoss Jo ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 892-895
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe colon specific drug delivery systems based on polysaccharides; locust bean gum and chitosan in the ratio of 2 : 3, 3 : 2 and 4 : 1 were evaluated using in vitro and in vivo methods. The in vitro studies in pH 6.8 phosphate buffer containing 2% w/v rat caecal contents showed that the cumulative percentage release of mesalazine after 26 h were 31.25±0.56, 46.25±0.96, 97.5±0.26 (mean±S.D.), respectively. The in vivo studies conducted in nine healthy male human volunteers for the various formulations revealed that, the drug release was initiated only after 5 h (i.e.) transit time of small intestine and the bioavailability (AUC0→t*) of the drug was found to be 85.24±0.10, 196.08±0.12, 498.62±0.10 μg h/ml 26 (mean±S.D.), respectively. These studies on the polysaccharides demonstrated that the combination of locust bean gum and chitosan as a coating material proved capable of protecting the core tablet containing mesalazine during the condition mimicking mouth to colon transit. In particular, the formulation containing locust bean gum and chitosan in the ratio of 4 : 1 held a better dissolution profile, higher bioavailability and hence a potential carrier for drug targeting to colon.View full abstractDownload PDF (57K) -
Li-hua Xie, Xuan Wang, Purusotam Basnet, Naoko Matsunaga, Seiichi Yama ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 896-899
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSMicellar electrokinetic chromatography (MEKC) conditions were developed to analyze the constituents of Scutellariae Radix (SR) and Scutellaria baicalensis roots. Using the MEKC method, the major flavonoid constituents of baicalin, baicalein and wogonin of wild and cultivated S. baicalensis roots were compared. In a preliminary comparison of electropherogram, one special peak was found in a wild sample but not in a 2-year-cultivated one. The compound corresponding to the peak was isolated and identified as a phenylethanoid glycoside, acteoside, by comparing the 1H- and 13C-NMR spectral data with that of the authentic compound. This is the first time acteoside has been isolated from the Scutellaria genus. It could only be found in SR derived from wild S. baicalensis roots and 4-year-cultivated plants, but not in plant materials cultivated for 3 years. Applying the MEKC method established in this study, rapid and simultaneous determinations of acteoside together with 3 flavonoids in samples were achieved. The method can thus be used for the quality control of SR in a shorter analysis period than HPLC.View full abstractDownload PDF (74K) -
Da Wei Li, Eun Bang Lee, Sam Sik Kang, Jin Ee Hyun, Wan Kyun WhangArticle type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 900-903
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSBy bioassay-guided separation, a known saponin, kalopanaxsaponin A (1) and a new saponin, pictoside A (2) were isolated from the stem bark of Kalopanax pictus as anti-inflammatory components when evaluated by vascular permeability test. Another novel saponin, pictoside B (3) was also isolated but was inactive in the test system used. The structures of pictosides A and B were elucidated as caulophyllogenin 3-O-α-L-rhamnopyranosyl(1→2)-α-L-arabinopyranoside (2) and pictogenin (3β,6β,16α,23-tetrahydroxyolean-12-ene-28-oic acid) 3-O-α-L-arabinopyranoside (3), respectively, by spectral analysis and by chemical degradation. Kalopanaxsaponin A and pictoside A showed significant anti-inflammatory activity at the oral doses of 50 mg/kg.View full abstractDownload PDF (65K) -
Eleni Rekka, Michael Chrysselis, Ioanna Siskou, Angeliki KourounakisArticle type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 904-907
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe relationship between free radicals and acute or chronic inflammation has been well established. We have previously reported the significant antioxidant activity of the natural azulene derivatives chamazulene and guaiazulene. Furthermore, some synthetic azulene analogues have been found to possess anti-inflammatory activity. In this investigation we report the synthesis of five 3-alkyl or 3-(hydroxy)alkylazulene-1-carboxylic acids and esters, from tropolone, via the corresponding furanone. The synthesised compounds were tested for their effect on the peroxidation of rat hepatic microsomal membrane lipids, applying the 2-thiobarbituric acid test. Their anti-inflammatory activity was evaluated in vitro by the offered inhibition of soybean lipoxygenase. All the tested molecules were found to inhibit lipid peroxidation by 100% at 1 mM. They were also found to considerably inhibit lipoxygenase activity. The above results are discussed in relation to the structure and physicochemical properties of the examined azulene derivatives.View full abstractDownload PDF (63K) -
Tomio Shimizu, Masaya Ishizaki, Nobuo NitadaArticle type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 908-921
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe regio- and stereoselectivity of the 1,3-dipolar cycloaddition reactions of C-aryl-N-alkylaldonitrones (1a—e) with some alkenes were found to be affected significantly by the addition of Lewis acid. The rate of the reaction was also affected by adding the Lewis acid. In the reactions using allyl alcohol as a dipolarophile an addition of Lewis acid caused a remarkable acceleration of the reaction and a great change in the stereoselectivity. In the reactions using ethyl acrylate as a dipolarophile the regioselectivity was reversed whether the reaction was performed in the presence or the absence of Lewis acid; i.e. isoxazolidine-5-carboxylates were obtained mainly in the absence of Lewis acid although isoxazolidine-4-carboxylates were obtained mainly in the presence of Lewis acid. When the reaction of C,N-diarylaldonitrones (1k, 1m, 1n) with ethyl acrylate was carried out in the presence of Lewis acid, the cleavage of the N–O bond of the cycloadducts giving γ-aminoalcohols was also observed besides a reverse phenomenon of regioselectivity.View full abstractDownload PDF (142K) -
Toshihiko Kaneko, Richard S. J. Clark, Norihito Ohi, Tetsuya Kawahara, ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 922-929
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSDuring a search for novel, orally-active inhibitors of upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), we found a new series of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives to be potent ICAM-1 inhibitors. Of these compounds, N-[1-(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)piperidin-4-yl]-N′,N′-dimethylsulfamide 7p showed the potent oral inhibitory activities against neutrophil migration in a murine interleukin-1 (IL-1) induced paw inflammation model. The synthesis and structure–activity relationships of these amide derivatives are described.View full abstractDownload PDF (97K) -
Masako Kinoshita, Mahisa Ohtsuka, Daisuke Nakamura, Hiroyuki AkitaArticle type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 930-934
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSFirst synthesis of (+)-α-polypodatetraene (1) and (+)-γ-polypodatetraene (2) was achieved from (+)-albicanol (6) and (−)-drimenol (8), respectively. The absolute structure of natural (+)-2 was established to be (5S,9S,10S)-polypoda-7,13(E),17(E),21-tetraene.View full abstractDownload PDF (75K) -
Naoko Morisaki, Hisayoshi Kobayashi, Yumiko Yamamura, Masuo Morisaki, ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 935-940
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSSteroidal allylic alcohols formed Na+ adduct ion peaks [M+Na]+ by the addition of NaCl in FAB mass spectrometry. A comparison of the intensities of the adduct ion peaks of allylic alcohols with those of the corresponding saturated alcohols and olefin suggested that the olefinic double bond and the proximal hydroxyl group had coordinated to Na+. The adduct ion was stable and did not undergo dehydroxylation. We suggest that the Na+ adduction will be useful for the molecular weight determination of allylic alcohols which are susceptible to dehydroxylation under FAB mass spectrometric conditions. Na+ adduct ions of α,β-unsaturated carbonyl compounds were also investigated.View full abstractDownload PDF (84K) -
Yoshimi Hirokawa, Hiroshi Harada, Takashi Yoshikawa, Naoyuki Yoshida, ...Article type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 941-959
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSIn search of a dopamine D2 and serotonin 5-HT3 receptors dual antagonist as a potential broad antiemetic agent, a number of benzamides were prepared from 4-amino-5-chloro-2-methoxybenzoic acid derivatives and 6-amino-1,4-dialkylhexahydro-1,4-diazepines and evaluated for their binding affinity for the dopamine D2 and the serotonin 5-HT3 receptors using rat brain synaptic and rat cortical membranes, respectively. From the results of both in vitro receptor binding and in vivo biological assays for the dopamine D2 receptor, 1-ethyl-4-methylhexahydro-1,4-diazepine ring was selected as an optimum amine moiety. Introduction of one methyl group on the nitrogen atom at the 4-position and/or modification of the substituent at the 5-position of the 4-amino-5-chloro-2-methoxybenzoyl moiety caused a marked increase in the dopamine D2 receptor binding affinity along with a potent 5-HT3 receptor binding affinity. Among the compounds, 5-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-4-methylaminobenzamide (82), 5-bromo (110), and 5-iodo (112) analogues exhibited a much higher affinity for the dopamine D2 receptor than that of metoclopramide (IC50=17.5—61.0 nM vs. 483 nM). In particular, 82 showed a potent antagonistic activity for both receptors in vivo tests. Optical resolution of the racemate 82 brought about a dramatic change in the pharmacological profile with the (R)-enantiomer exhibiting a strong affinity for both the dopamine D2 and the 5-HT3 receptors, while the corresponding (S)-enantiomer had a potent and selective serotonin 5-HT3 receptor binding affinity.View full abstractDownload PDF (207K) -
Hiromitsu Takayama, Hayato Ishikawa, Mariko Kitajima, Norio AimiArticle type: Regular Article
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 960-963
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSLead tetraacetate oxidation of a Corynanthe-type indole alkaloid, mitragynine, produced mainly 7-acetoxyindolenine derivative (2) together with a dimeric compound (4) as a minor product. The novel structure having a bridge between the C-11′ and C-7 positions in the respective indolenine parts and its formation mechanism were studied.View full abstractDownload PDF (63K)
Notes
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Carmelo Rosquete, Esther Del Olmo, Francisca Sanz, Arturo San Felician ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 964-965
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSA symmetrical dimeric sesquiterpenoid, biatractylolide (1), was isolated from the resin of Trattinickia rhoifolia WILLD. The structure of compound 1 was elucidated by one- and two-dimensional NMR techniques and electron impact-mass spectra (EI-MS) data, and confirmed by X-ray crystallographic analysis.View full abstractDownload PDF (50K) -
Sizuka Ono, Kiyoshi Ogawa, Kanako Yamashita, Tamotsu Yamamoto, Yuji Ka ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 966-968
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESS(1S,2R)-1-Phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxamide (2b, PPDC), a new class of potent N-methyl-D-aspartic acid (NMDA) receptor antagonist, was designed based on a new method for restricting the conformation of compounds having a cyclopropane ring. The three-dimensional structures of PPDC obtained by the three different methods of X-ray crystallographic analysis, usual MM2-calculations in vacuum, and MM2 calculations based on the nuclear Overhauser effect (NOE) data in D2O are similar, which are in accord with that hypothesized. These results suggest that this conformational restriction method is particularly effective in designing novel biologically active molecules.View full abstractDownload PDF (64K) -
Hirohito Ikeda, Takuya Suzue, Miho Yukawa, Tokihiro Niiya, Yoshinobu G ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 969-971
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSPhotoisomerisation of (2E)- and (2Z)-3-methyl-1-phenylbutane-1,2-dione 2-oxime (MPBDO) in several solvents was studied. With increasing dielectric constants of solvents, kinetic constants of forward reactions (E-form→Z-form) did not change appreciably but those of reverse reactions (Z-form→E-form) decreased. The positive correlation was found between equilibrium constants of photoisomerisation and dielectric constants of solvents.View full abstractDownload PDF (41K) -
Hisashi Matsuda, Toshio Morikawa, Iwao Toguchida, Shoichi Harima, Masa ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 972-975
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSTwo new flavanone glycosides, (2S)- and (2R)-eriodictyol 7-O-β-D-glucopyranosiduronic acids, and a new phenylbutanoid glycoside, (2S, 3S)-1-phenyl-2,3-butanediol 3-O-β-D-glucopyranoside, were isolated from the flowers of Chrysanthemum indicum L. cultivated in China together with eight flavonoids. The absolute stereostructures of the new compounds were determined on the basis of chemical and physicochemical evidence. Both of the new flavanone glycosides were found to show inhibitory activity for rat lens aldose reductase.View full abstractDownload PDF (70K) -
Masashi Tsuda, Naoko Izui, Masaaki Sato, Jun'ichi KobayashiArticle type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 976-977
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe biosynthetic origins of amphidinolide W (1) were investigated on the basis of 13C-NMR data of 13C-enriched samples obtained by feeding experiments with [1-13C], [2-13C], and [1,2-13C2] sodium acetate in cultures of a strain Y-42 of the dinoflagellate Amphidinium sp. These incorporation patterns suggested that 1 was generated from a hexaketide chain, two acetate units, four isolated C1 units from C-2 of acetates, and four branched C1 units from C-2 of acetates. The acetate-incorporation patterns for C-1–C-2–(C-21) and C-8–C-18–(C-23, C-24) of 1 corresponded well to those for C-1–C-2–(C-27) and C-5–C-15–(C-28, C-29) of amphidinolide H (2) isolated from this strain.View full abstractDownload PDF (43K) -
Yueh-Hsiung Kuo, Chia-Hsien Chen, Yun-Lian LinArticle type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 978-980
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSFour new lignans, 3′,4′-O,O-demethylenehinokinin (1), chamalignolide (2), 8′β-hydroxyhinokinin (3) and 7β,8β-epoxyzuonin A (4), as well as (−)-hinokinin (5), and (−)-zuonin A (6), were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structures of these lignans were unambiguously determined by spectroscopic methods. And the absolute configuration of 1 was elucidated with a circular dichroism (CD) spectrum.View full abstractDownload PDF (54K) -
Nabil Semmar, Bernard Fenet, Katia Gluchoff-Fiasson, Gilles Comte, Mau ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 981-984
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSA new flavonol tetraglycoside, together with four acylated derivatives, were isolated from the leaves of Astragalus caprinus. Their structures were elucidated by spectroscopic methods, mainly 2D NMR, as kaempferol-3-O-{[β-D-xylopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)][α-L-rhamnopyranosyl(1→2)]}-β-D-galactopyranoside (1), its 3Gal-p-coumaric (2) and 3Gal-ferulic (3) esters, and its 4Gal-p-coumaric (4) and 4Gal-ferulic (5) esters.View full abstractDownload PDF (57K) -
Kensuke Okuda, Chiho Abeta, Takashi Hirota, Masataka Mochizuki, Tadahi ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 985-987
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSWater-soluble C60-porphyrin hybrid molecules were first synthesized toward their pharmaceutical applications.View full abstractDownload PDF (46K) -
Markus Ganzera, Jianping Zhao, Ilias Muhammad, Ikhlas Ahmad KhanArticle type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 988-991
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSLepidium meyenii (Maca) is one of the few plants that can be cultivated in the harsh climate of the Andes. Its nutritious hypocotyl is traditionally used as food and medicine, and Maca products are increasingly becoming popular in the western world as tonics. This paper describes the first analytical method allowing the determination of the main macamides and macaenes, the marker compounds of L. meyenii. A separation within 35 min was possible by using a C-12 stationary phase, an acidic mobile phase comprising of acetonitrile and water, and raising the column temperature to 40 °C. By monitoring the separation at 210 and 280 nm, the markers were detectable as low as 0.40 μg/ml. In order to validate the method, accuracy, precision, linearity, limit of detection and intra/inter day repeatability were determined. The analysis of several commercially available Maca products showed a similar qualitative pattern but significant differences in the quantitative composition. The percentage of total markers in the preparations varied from 0.15 to 0.84%, resulting in daily intakes for the consumer from 1.52 to 14.88 mg, respectively.View full abstractDownload PDF (51K) -
Akihito Yokosuka, Yoshihiro Mimaki, Yutaka SashidaArticle type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 992-995
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSFurther search for steroidal compounds contained in Dracaena surculosa (Agavaceae) led to the isolation of two new 3,5-cyclospirostanol saponins (1, 2) and two new 3,5-cyclofurostanol saponins (3, 4). Their structural assignment was established by spectroscopic analysis and a few chemical transformations as (24S,25R)-1β-[(β-D-fucopyranosyl)oxy]-6β-hydroxy-3α,5α-cyclospirostan-24-yl β-D-glucopyranoside (1), (24S,25R)-1β-[(β-D-glucopyranosyl)oxy]-6β-hydroxy-3α,5α-cyclospirostan-24-yl β-D-glucopyranoside (2), (25S)-1β-[(β-D-glucopyranosyl)oxy]-6β-hydroxy-22α-methoxy-3α,5α-cyclofurostan-26-yl β-D-glucopyranoside (3), and (25S)-1β-[(β-D-fucopyranosyl)oxy]-6β-hydroxy-22α-methoxy-3α,5α-cyclofurostan-26-yl β-D-glucopyranoside (4), respectively.View full abstractDownload PDF (59K) -
Shizuyo Horiyama, Kiyoko Suwa, Masae Yamaki, Hiromi Kataoka, Toyoshi K ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 996-1000
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSHydroxylamines gradually undergo oxidation to their oximes on being dissolved in organic solvent (e.g. methanol). This phenomenon was followed by 1H-NMR and liquid chromatography-mass spectrometry (LC-MS). The oxidation rate was estimated from the peak area observed on the mass chromatogram at the protonated molecule or fragment ion on LC-atmospheric pressure chemical ionization (APCI)-MS. The results showed that the oxidation rate of hydroxylamines depended on the solvent type.View full abstractDownload PDF (69K) -
Keiko Hojo, Yuichi Susuki, Masahiko Sasaki, Mitsuko Maeda, Timothy Joh ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 1001-1003
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSAn amino acid type poly(ethylene glycol) is a useful tool for preparation of a bi- or multivalent poly(ethylene glycol) hybrid of bioactive peptides, but synthesis is problematic. The amino acid type poly(ethylene glycol) was prepared from poly(oxyethylene)diglycolic acid followed by introduction of a fluorenylmethyloxycarbonyl group. The resulting product could be purified easily by LH-20 column chromatography and HPLC.View full abstractDownload PDF (53K) -
Makoto Hashimoto, Jing Yang, Yasumaru Hatanaka, Yutaka Sadakane, Kazuy ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 1004-1006
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSWe have developed two novel 3-phenyl-3-trifluoromethyldiazirinyl bis-glucose derivatives to investigate the properties of the adipocyte glucose transporter GLUT4. These compounds were substituted by electron-withdrawing (iodo and nitro) groups on the aromatic ring of 3-phenyl-3-trifluoromethyldiazirine photophore and were found to be more photosensitive than compounds without such substituents. The compounds were used as inhibitors of insulin-stimulated glucose transport activity in order to assess half-maximal inhibition or relative affinity values for GLUT4. The affinities were found to be 60—130 times higher than the parent compound D-glucose. Because of the increased photo-reactivity and high affinity these compounds will be useful in studies directed at further elucidation of GLUT4 function.View full abstractDownload PDF (55K) -
Tadamasa Terai, Huifeng Ren, Go Mori, Yoshihito Yamaguchi, Tetsuhito H ...Article type: Note
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 1007-1010
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSStevioside is natural non-caloric sweetner isolated from Stevia rebaudiana BERTONI, which has been used as a non-caloric sugar substitute in Japan. Pezzuto et al. demonstrated that steviol shows a dose-dependent positive response in forward mutation assay using Salmonella typhimurium TM677 in the presence of metabolic activation system (Aroclor induced rat liver S9 fraction). Our studies were carried out to identify the genuine mutagenic active substance from among the eight steviol derivatives. Steviol indicate almost similar levels of mutagenicity under the presence of S9 mixture, as reported by Pezzuto et al. 15-Oxo-steviol was found to be mutagenic at the one tenth the level of steviol itself under the presence of S9 mixture. Interestingly, specific mutagenicity of the lactone derivative under the presence of S9 mixture was ten times lower than that of the lactone derivative without the addition of S9 mixture.View full abstractDownload PDF (68K)
Communicatins to the Editor
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Yasuo Takeuchi, Kumiko Azuma, Hitoshi Abe, Kenji Sasaki, Takashi Haray ...Article type: Communication to the Editor
Subject area: [not specified]
2002 Volume 50 Issue 7 Pages 1011-1012
Published: 2002
Released on J-STAGE: July 01, 2002
JOURNAL FREE ACCESSThe stereo structure of piperidine lactone (3), an intermediate of the antimalarial agent febrifugine ((+)-1) prepared by a synthetic method, was re-revised to the cis-form from the trans-form.View full abstractDownload PDF (45K)
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