Convenient Indole Synthesis from 2-Iodoanilines and Terminal Alkynes by the Sequential Sonogashira Reaction and the Cyclization Reaction Promoted by Tetrabutylammonium Fluoride (TBAF)

Naoyuki Suzuki; Sakura Yasaki; Akito Yasuhara; Takao Sakamoto

doi:10.1248/cpb.51.1170

Regular Articles

Convenient Indole Synthesis from 2-Iodoanilines and Terminal Alkynes by the Sequential Sonogashira Reaction and the Cyclization Reaction Promoted by Tetrabutylammonium Fluoride (TBAF)

Naoyuki Suzuki, Sakura Yasaki, Akito Yasuhara, Takao Sakamoto

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Keywords: indole, sequential cyclization, palladium-catalyzed reaction, 2-ethynylaniline, tetrabutylammnonium fluoride, terminal alkyne

JOURNAL FREE ACCESS

2003 Volume 51 Issue 10 Pages 1170-1173

DOI https://doi.org/10.1248/cpb.51.1170

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Abstract

The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.

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