Urinary Metabolites of Nobiletin Orally Administered to Rats

Takaaki Yasuda; Yukako Yoshimura; Hisako Yabuki; Takahiro Nakazawa; Keisuke Ohsawa; Yoshihiro Mimaki; Yutaka Sashida

doi:10.1248/cpb.51.1426

Notes

Urinary Metabolites of Nobiletin Orally Administered to Rats

Takaaki Yasuda, Yukako Yoshimura, Hisako Yabuki, Takahiro Nakazawa, Keisuke Ohsawa, Yoshihiro Mimaki, Yutaka Sashida

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Keywords: nobiletin, metabolism, Citrus depressa, polymethoxyflavone, demethylation

JOURNAL FREE ACCESS

2003 Volume 51 Issue 12 Pages 1426-1428

DOI https://doi.org/10.1248/cpb.51.1426

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Abstract

During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4′-hydroxy-3′,5,6,7,8-pentamethoxyflavone (1).

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