Anti-diabetes Effect of Zn(II)/Carnitine Complex by Oral Administration

抄録

A novel bis(L-carnitinato)Zn(II) complex, Zn(car)₂Cl₂, was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A^y mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight).