Gluco-indole Alkaloids from Nauclea cadamba in Thailand and Transformation of 3α-Dihydrocadambine into the Indolopyridine Alkaloid, 16-Carbomethoxynaufoline

Hiromitsu Takayama; Shun-ichiro Tsutsumi; Mariko Kitajima; Dammrong Santiarworn; Boonsom Liawruangrath; Norio Aimi

doi:10.1248/cpb.51.232

Communicatins to the Editor

Gluco-indole Alkaloids from Nauclea cadamba in Thailand and Transformation of 3α-Dihydrocadambine into the Indolopyridine Alkaloid, 16-Carbomethoxynaufoline

Hiromitsu Takayama, Shun-ichiro Tsutsumi, Mariko Kitajima, Dammrong Santiarworn, Boonsom Liawruangrath, Norio Aimi

著者情報

キーワード: Nauclea cadamba, indole alkaloid, gluco alkaloid, structure elucidation, trasformation

ジャーナルフリー

2003 年 51 巻 2 号 p. 232-233

DOI https://doi.org/10.1248/cpb.51.232

詳細

抄録

Three monoterpenoid gluco-indole alkaloids, 3β-isodihydrocadambine, cadambine, and 3α-dihydrocadambine, were isolated from Nauclea cadamba ROXB. growing in Thailand. The stereochemistry at C19 in 3β-isodihydrocadambine was elucidated to be R by spectroscopic analysis. Treatment of 3α-dihydrocadambine with β-glucosidase in aqueous ammonium acetate solution gave an indolopyridine alkaloid, 16-carbomethoxynaufoline, and an unusually rearranged compound.

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