Preparation of 9-Hydroxy Grayanotoxin Derivatives and Their Acute Toxicity in Mice

Tadamasa Terai; Kanehiro Osakabe; Masaaki Katai; Ken-ichi Sakaguchi; Isao Narama; Tetsuro Matsuura; Jun'ichi Katakawa; Tadahiro Tetsumi

doi:10.1248/cpb.51.351

Notes

Preparation of 9-Hydroxy Grayanotoxin Derivatives and Their Acute Toxicity in Mice

Tadamasa Terai, Kanehiro Osakabe, Masaaki Katai, Ken-ichi Sakaguchi, Isao Narama, Tetsuro Matsuura, Jun'ichi Katakawa, Tadahiro Tetsumi

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Keywords: grayanotoxin II, 9-hydroxy grayanotoxins, acute toxicity, lethal dosage, X-ray analysis

JOURNAL FREE ACCESS

2003 Volume 51 Issue 3 Pages 351-353

DOI https://doi.org/10.1248/cpb.51.351

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Abstract

Novel 9α and 9β-hydroxy grayanotoxin II derivatives were prepared by photo-sensitized oxygenation of iso-grayanotoxin II and oxidation of grayanotoxin II tetraacetate with selenium dioxide respectively. The lethal dosage of 9α and 9β-hydroxy grayanotoxin II were lower than that of grayanotoxin II. In addition, the lethal dosage of 9β-hydroxy-dihydro grayanotoxin II was higher than that of dihydro grayanotoxin II.

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