Three New Quassinoids, Ailantinol E, F, and G, from Ailanthus altissima

Sadaaki Tamura; Narihiko Fukamiya; Masayoshi Okano; Junko Koyama; Kazuo Koike; Harukuni Tokuda; Wataru Aoi; Junko Takayasu; Masashi Kuchide; Hoyoku Nishino

doi:10.1248/cpb.51.385

Regular Articles

Three New Quassinoids, Ailantinol E, F, and G, from Ailanthus altissima

Sadaaki Tamura, Narihiko Fukamiya, Masayoshi Okano, Junko Koyama, Kazuo Koike, Harukuni Tokuda, Wataru Aoi, Junko Takayasu, Masashi Kuchide, Hoyoku Nishino

Author information

Sadaaki Tamura
Faculty of Integrated Arts and Sciences, Hiroshima University
Narihiko Fukamiya
Faculty of Integrated Arts and Sciences, Hiroshima University
Masayoshi Okano
Faculty of Integrated Arts and Sciences, Hiroshima University
Junko Koyama
Faculty of Pharmaceutical Science, Kobe Pharmaceutical University
Kazuo Koike
School of Pharmaceutical Sciences, Toho University
Harukuni Tokuda
Department of Biochemistry, Kyoto Prefectural University of Medicine
Wataru Aoi
Department of Biochemistry, Kyoto Prefectural University of Medicine
Junko Takayasu
Department of Biochemistry, Kyoto Prefectural University of Medicine
Masashi Kuchide
Department of Biochemistry, Kyoto Prefectural University of Medicine
Hoyoku Nishino
Department of Biochemistry, Kyoto Prefectural University of Medicine

Keywords: quassinoid, Ailanthus altissima, Simaroubaceae, inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation

JOURNAL FREE ACCESS

2003 Volume 51 Issue 4 Pages 385-389

DOI https://doi.org/10.1248/cpb.51.385

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Abstract

Three new quassinoids, ailantinol E (1), ailantinol F (2), and ailantinol G (3), and related compounds were isolated from Ailanthus altissima grown in Taiwan. Their structures were elucidated from spectral evidence. Each new quassinoid was evaluated for its antitumor promoting effects against Epstein-Barr virus early antigen activation introduced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The new quassinoids were found to show potent activity without showing any cytotoxicity. The screening for inhibitors against nitric oxide donor action was also conducted using the new quassinoids and some standard samples.

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