Cholinesterase Inhibitory Constituents from Onosma hispida

Abstract

Hispidone, a new flavanone, has been isolated from Onosma hispida and assigned the structure (2S)-5,2′-dihydroxy-7,4′,5′-trimethoxyflavanone (1) by spectroscopic methods. In addition, (2S)-5,2′-dihydroxy-7,5′-dimethoxyflavanone (2), benzoic acid (3), and 4-hydroxy benzoic acid (4) are also reported for the first time from this species.