Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
Three New Ingol Diterpenes from Euphorbia nivulia: Evaluation of Cytotoxic Activity
Veluri Ravikanth, Vanimireddy Lakshmi Niranjan Reddy, Adelli Vijender Reddy, Kodela Ravinder, Tadikamalla Prabhakar Rao, Tejomoorty Siva Ram, Kondapi Anand Kumar, Diwan Prakesh Vamanarao, Yenamandra Venkateswarlu
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Keywords: Euphorbia nivulia, Euphorbiaceae, ingol diterpenoids, cytotoxic activity
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2003 Volume 51 Issue 4 Pages 431-434

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Abstract

The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2—6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2—9 were evaluated for their cytotoxic activity.

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© 2003 The Pharmaceutical Society of Japan
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