Preparation and Cancer Cell Invasion Inhibitory Effects of C16-Alkynic Fatty Acids

Kazuyoshi Ohashi; Hendig Winarno; Mutsuko Mukai; Hirotaka Shibuya

doi:10.1248/cpb.51.463

Notes

Preparation and Cancer Cell Invasion Inhibitory Effects of C₁₆-Alkynic Fatty Acids

Kazuyoshi Ohashi, Hendig Winarno, Mutsuko Mukai, Hirotaka Shibuya

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Keywords: C₁₆-alkynic fatty acid, cancer cell invasion inhibitory effect, anticancer, hexadeca-6,8,10-triynoic acid, hexadeca-8,10,12-triynoic acid

JOURNAL FREE ACCESS

2003 Volume 51 Issue 4 Pages 463-466

DOI https://doi.org/10.1248/cpb.51.463

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Abstract

Five C₁₆-alkynic fatty acids (2—6) were prepared and examined their inhibitory effects on cancer cell invasion. It has been found that hexadeca-6,8,10-triynoic acid (5) and hexadeca-8,10,12-triynoic acid (6) exhibit similar potent inhibitory activities with that of octadeca-8,10,12-triynoic acid (1) which was isolated from Scurrula atropurpurea (Loranthaceae).

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