Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Phenylpropanoid Glycosides from Rhodiola rosea
Ari TolonenMinna PakonenAnja HohtolaJorma Jalonen
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2003 Volume 51 Issue 4 Pages 467-470


Rhodiola rosea L. (Golden Root) has been used for a long time as an adaptogen in Chinese traditional medicine and is reported to have many pharmacological properties. Along its known secondary metabolites tyrosol (1), salidroside (rhodioloside) (2), rosin (3), rosarin (4), rosavin (5), sachaliside 1 (6) and 4-methoxy-cinnamyl-O-β-D-glucopyranoside (7), four compounds were isolated from aqueous methanol extract of the plant and identified as cinnamyl-(6′-O-β-xylopyranosyl)-O-β-glucopyranoside (8), 4-methoxy-cinnamyl-(6′-O-α-arabinopyranosyl)-O-β-glucopyranoside (9), picein (10) and benzyl-O-β-glucopyranoside (11) by UV, MS and NMR methods. Compounds 8 and 9 are new natural compounds whereas compounds 10 and 11 were isolated first time from R. rosea. Also the compounds 6 and 7 are isolated earlier only from the callus cultures of the plant but not from the differentiated plant.

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© 2003 The Pharmaceutical Society of Japan
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