First Natural Urease Inhibitor from Euphorbia decipiens

Viqar Uddin Ahmad; Javid Hussain; Hidayat Hussain; Amir Reza Jassbi; Farman Ullah; Muhammad Arif Lodhi; Amsha Yasin; Muhammad Iqbal Choudhary

doi:10.1248/cpb.51.719

Notes

First Natural Urease Inhibitor from Euphorbia decipiens

Viqar Uddin Ahmad, Javid Hussain, Hidayat Hussain, Amir Reza Jassbi, Farman Ullah, Muhammad Arif Lodhi, Amsha Yasin, Muhammad Iqbal Choudhary

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Keywords: Euphorbia decipiens, Euphorbiaceae, diterpene ester, myrsinol-type diterpene, urease, prolyl endopeptidase

JOURNAL FREE ACCESS

2003 Volume 51 Issue 6 Pages 719-723

DOI https://doi.org/10.1248/cpb.51.719

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Abstract

Three new diterpene esters with a myrsinol-type skeleton have been isolated from Euphorbia decipiens BOISS. & BUHSE. The structure elucidation of the isolated compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC) and nuclear Overhauser effect spectroscopy (NOESY) experiments. Compounds 1 and 3 are active against prolyl endopeptidase and compound 2 showed inhibitory activity against urease enzyme.

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