Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica

Souichi Kawamoto; Takashi Koyano; Thaworn Kowithayakorn; Haruhiro Fujimoto; Emi Okuyama; Masahiko Hayashi; Kanki Komiyama; Masami Ishibashi

doi:10.1248/cpb.51.737

Notes

Wrightiamines A and B, Two New Cytotoxic Pregnane Alkaloids from Wrightia javanica

Souichi Kawamoto, Takashi Koyano, Thaworn Kowithayakorn, Haruhiro Fujimoto, Emi Okuyama, Masahiko Hayashi, Kanki Komiyama, Masami Ishibashi

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Keywords: Apocynaceae, Wrightia javanica, pregnane alkaloid, cytotoxicity

JOURNAL FREE ACCESS

2003 Volume 51 Issue 6 Pages 737-739

DOI https://doi.org/10.1248/cpb.51.737

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Abstract

Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3β-hydroxy-5α-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.

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