New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin

Fumiyuki Kiuchi; Kenji Matsuo; Michiho Ito; Tran Kim Qui; Gisho Honda

doi:10.1248/cpb.52.1495

Notes

New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin

Fumiyuki Kiuchi, Kenji Matsuo, Michiho Ito, Tran Kim Qui, Gisho Honda

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Keywords: Pogostemon cablin, Labiatae, sesquiterpene hydroperoxide, trypanocidal constitutent, Trypanosoma cruzi

JOURNAL FREE ACCESS

2004 Volume 52 Issue 12 Pages 1495-1496

DOI https://doi.org/10.1248/cpb.52.1495

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Abstract

Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1—3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1—3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

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