Nigellamines A3, A4, A5, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin

Toshio Morikawa; Fengming Xu; Kiyofumi Ninomiya; Hisashi Matsuda; Masayuki Yoshikawa

doi:10.1248/cpb.52.494

Communications to the Editor

Nigellamines A₃, A₄, A₅, and C, New Dolabellane-Type Diterpene Alkaloids, with Lipid Metabolism-Promoting Activities from the Egyptian Medicinal Food Black Cumin

Toshio Morikawa, Fengming Xu, Kiyofumi Ninomiya, Hisashi Matsuda, Masayuki Yoshikawa

著者情報

キーワード: Nigella sativa, black cumin, nigellamine, dolabellane-type diterpene, lipid metabolism-promoting activity, Egyptian medicinal food

ジャーナルフリー

2004 年 52 巻 4 号 p. 494-497

DOI https://doi.org/10.1248/cpb.52.494

詳細

抄録

New dolabellane-type diterpene alkaloids, nigellamines A₃, A₄, A₅, and C, were isolated from the methanolic extract of an Egyptian medicinal food, black cumin (the seeds of Nigella sativa). Their absolute configurations were determined on the basis of chemical and physicochemical evidence. Nigellamines were found to lower triglyceride levels in primary cultured mouse hepatocytes, and in particular, the activity of nigellamine A₅ was equivalent to that of the hypolipidemic agent, clofibrate.

責任著者(Corresponding author)

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