Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Communications to the Editor
Effect of Freeze-Thawing and Polyethylene Glycol (PEG) Lipid on Fusion and Fission of Phospholipid Vesicles
Supaporn SriwongsitanontMasaharu Ueno
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2004 年 52 巻 5 号 p. 641-642

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The effect of freeze-thawing on the size of egg yolk phosphatidylcholine (EggPC) vesicles in the presence of 0—40 mol% distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE-PEG) was studied. Mean diameters of the vesicles fell into a range of 80—150 nm after 10 times freeze-thawing in spite of their original size. In the process of freeze-thawing, two opponent events, one is fission and the other is fusion, occurred at the same time. DSPE-PEG accelerated the fusion event.
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© 2004 The Pharmaceutical Society of Japan
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