Evaluation of Homology Modeling of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease for Structure Based Drug Design

Mayuko Takeda-Shitaka; Hiroyuki Nojima; Daisuke Takaya; Kazuhiko Kanou; Mitsuo Iwadate; Hideaki Umeyama

doi:10.1248/cpb.52.643

Communications to the Editor

Evaluation of Homology Modeling of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease for Structure Based Drug Design

Mayuko Takeda-Shitaka, Hiroyuki Nojima, Daisuke Takaya, Kazuhiko Kanou, Mitsuo Iwadate, Hideaki Umeyama

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Keywords: homology modeling, severe acute respiratory syndrome (SARS), normal mode analysis, structure based drug design

JOURNAL FREE ACCESS

2004 Volume 52 Issue 5 Pages 643-645

DOI https://doi.org/10.1248/cpb.52.643

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Abstract

To accelerate the development of drugs against severe acute respiratory syndrome (SARS), we constructed a homology model of the SARS coronavirus main protease using our modeling software, FAMS Ligand&Complex, and released it before the X-ray structure was solved. The X-ray structure showed our model as accurately predicted and useful for structure based drug design.

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