3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

Dejan D. Đoković; Vanja M. Bulatović; Biljana Đ. Božić; Milena V. Kataranovski; Tomislav M. Zrakić; Nada N. Kovačević

doi:10.1248/cpb.52.853

Notes

3,5-Nonadiyne Isolated from the Rhizome of Cachrys ferulacea Inhibits Endogenous Nitric Oxide Release by Rat Peritoneal Macrophages

Dejan D. Đoković, Vanja M. Bulatović, Biljana Đ. Božić, Milena V. Kataranovski, Tomislav M. Zrakić, Nada N. Kovačević

著者情報

キーワード: 3,5-nonadiyne, Cachrys ferulacea, Prangos ferulacea, endogenous nitric oxide, inhibition

ジャーナルフリー

2004 年 52 巻 7 号 p. 853-854

DOI https://doi.org/10.1248/cpb.52.853

詳細

抄録

3,5-Nonadiyne, in vitro, selectively inhibits endogenous nitric oxide release (IC₅₀=6.7±0.8 μM) by rat peritoneal macrophages at doses that do not inhibit T cell proliferation. 3,5-Nonadiyne was isolated from root essential oil of Cachrys ferulacea (L.) CALESTANI, synonym Prangos ferulacea (L.) LINDLEY, obtained by hydrodistillation and spectrometricaly identified unambiguously.

責任著者(Corresponding author)

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