N-Phenylphthalimide-Type Cyclooxygenase (COX) Inhibitors Derived from Thalidomide: Substituent Effects on Subtype Selectivity

Hiroko Sano; Tomomi Noguchi; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.52.1021

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

Notes

N-Phenylphthalimide-Type Cyclooxygenase (COX) Inhibitors Derived from Thalidomide: Substituent Effects on Subtype Selectivity

Hiroko Sano, Tomomi Noguchi, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

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Keywords: Thalidomide, N-substituted phenylphthalimide, cyclooxygenase (COX), selectivity

JOURNALS FREE ACCESS

Volume 52 (2004) Issue 8 Pages 1021-1022

DOI https://doi.org/10.1248/cpb.52.1021

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Abstract

Several N-substituted phenylphthalimide and phenylhomophthalimide derivatives with cyclooxygenase (COX)-inhibitory activity were prepared during structural development studies based on thalidomide as a lead compound. Substituent effects on the subtype selectivity were investigated.

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