A New Synthetic Method for an Indolizidine Skeleton by C–N Bond Formation via a π-Allylpalladium Complex

Yaeko Yamada; Wakako Takahashi; Yoshihisa Asada; Junko Holiuchi; Kazuyoshi Takeda; Yoshihiro Harigaya

doi:10.1248/cpb.52.1082

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A New Synthetic Method for an Indolizidine Skeleton by C–N Bond Formation via a π-Allylpalladium Complex

Yaeko Yamada, Wakako Takahashi, Yoshihisa Asada, Junko Holiuchi, Kazuyoshi Takeda, Yoshihiro Harigaya

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Keywords: π-allylpalladium complex, indolizidine, Pd(0), C–N bond formation

JOURNAL FREE ACCESS

2004 Volume 52 Issue 9 Pages 1082-1085

DOI https://doi.org/10.1248/cpb.52.1082

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Abstract

Pd(0)-catalyzed intramolecular cyclic reaction via a π-allylpalladium complex provided an indolizidine skeleton in satisfactory high and reproducible yields by using allylic compound having an acetoxyl group as a leaving group. These results must be available for syntheses of various functional indolizidine alkaloids.

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