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Chemical and Pharmaceutical Bulletin
Vol. 52 (2004) No. 9 P 1140-1142




A glycosyl inositolphosphoceramide-type ganglioside, CJP4, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthus japonica. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 9-O-methyl-(N-glycolyl-α-D-neuraminosyl)-(2→11)-9-O-methyl-(N-glycolyl-α-D-neuraminosyl)-(2→11)-9-O-methyl-(N-glycolyl-α-D-neuraminosyl)-(2→3)-inositolphosphoceramide, which contains C16-sphingosine and C22:0-, C24:0-fatty acid. This is the first report on the isolation and structural elucidation of a trisialo-glycosyl inositolphosphoceramide-type ganglioside. Moreover, CJP4 exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor.

Copyright © 2004 The Pharmaceutical Society of Japan

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