Tyrosinase-Inhibitory Long-Chain Esters from Amberboa ramosa

Sher Bahadar Khan; Azhar-ul-haq; Nighat Afza; Abdul Malik; Mahmud Tariq Hasan Khan; Muhammad Raza Shah; Muhammad Iqbal Choudhary

doi:10.1248/cpb.53.86

Notes

Tyrosinase-Inhibitory Long-Chain Esters from Amberboa ramosa

Sher Bahadar Khan, Azhar-ul-haq, Nighat Afza, Abdul Malik, Mahmud Tariq Hasan Khan, Muhammad Raza Shah, Muhammad Iqbal Choudhary

Author information

Sher Bahadar Khan
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
Azhar-ul-haq
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
Nighat Afza
Pharmaceutical Research Centre, PCSIR Laboratories-Complex Karachi
Abdul Malik
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
Mahmud Tariq Hasan Khan
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
Muhammad Raza Shah
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi
Muhammad Iqbal Choudhary
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research, University of Karachi

Keywords: Amberboa ramosa, Compositae, long-chain ester, tyrosinase inhibition

JOURNAL FREE ACCESS

2005 Volume 53 Issue 1 Pages 86-89

DOI https://doi.org/10.1248/cpb.53.86

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Abstract

Long-chain esters 1 and 2 have been isolated from the chloroform-soluble fraction of Amberboa ramosa and their structures assigned to be methyl 2β(2S)-hydroxyl-7(E)-tritriacontenoate (1) and methyl 2β(2S)-O-β-D-galactopyranosyl-7(E)-tetratriacontenoate (2). In addition, tricontane (3) and apigenin (4) are also reported for the first time from this species. The structures were assigned on the basis of 1D and 2D NMR techniques. Compounds 1 and 2 showed strong to moderate inhibitory activity against tyrosinase.

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