Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Notes
Interaction between Quaternary Ammonium Ions and Dipeptides: Positive Anion Allosteric Effect
Kazuaki ItoKayo NagaseNaoya MorohashiYoshihiro Ohba
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2005 年 53 巻 1 号 p. 90-94

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The binding properties of dipeptides possessing aromatic residues towards quaternary ammonium ions have been investigated by 1H-NMR spectroscopy. The intermolecular hydrogen bonding between exchangeable protons (OH and NH) of aromatic residues of dipeptides and the counter anion of ammonium ion is the primary force. After the formation of the intermolecular hydrogen bonding, two aromatic residues of dipeptides can provide π-base cavity to interact with the quaternary ammonium moiety.
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© 2005 The Pharmaceutical Society of Japan
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