Constituents of Holothuroidea, 16. Determination of Absolute Configuration of the Branched Methyl Group in Ante-iso Type Side Chain Moiety on Long Chain Base of Glucocerebroside from the Sea Cucumber Holothuria leucospilota

Koji Yamada; Hiroyuki Onaka; Masakazu Tanaka; Masanori Inagaki; Ryuichi Higuchi

doi:10.1248/cpb.53.1333

Notes

Constituents of Holothuroidea, 16. Determination of Absolute Configuration of the Branched Methyl Group in Ante-iso Type Side Chain Moiety on Long Chain Base of Glucocerebroside from the Sea Cucumber Holothuria leucospilota

Koji Yamada, Hiroyuki Onaka, Masakazu Tanaka, Masanori Inagaki, Ryuichi Higuchi

著者情報

キーワード: glycosphingolipid, glucocerebroside, absolute configuration, sea cucumber, Holothuria leucospilota

ジャーナルフリー

2005 年 53 巻 10 号 p. 1333-1334

DOI https://doi.org/10.1248/cpb.53.1333

詳細

抄録

The absolute configuration of the branched methyl group in ante-iso type side chain moiety on the long chain base of glucocerebroside, HLC-2-A, which was isolated from the sea cucumber Holothuria leucospilota was determined. Oxidation of the glucocerebroside with ozone afforded C₁₃-fragment including the ante-iso moiety. The optically active C₁₃-fragment was synthesized asymmetrically by using the Wittig reaction from chiral synton for comparison with the natural fragment.

責任著者(Corresponding author)

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