Preparation of 4-Pentenoic Acid Ester of Neu5Ac and 4-Pentenyl Glycoside of Neu5Ac and Their Application to Glycosylation

Kiyoshi Ikeda; Jun Fukuyo; Kazuki Sato; Masayuki Sato

doi:10.1248/cpb.53.1490

Notes

Preparation of 4-Pentenoic Acid Ester of Neu5Ac and 4-Pentenyl Glycoside of Neu5Ac and Their Application to Glycosylation

Kiyoshi Ikeda, Jun Fukuyo, Kazuki Sato, Masayuki Sato

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Keywords: 4-pentenoic acid ester, 4-pentenyl glycoside, N-acetylneuraminic acids, O-sialylation, armed-disarmed methodology

JOURNAL FREE ACCESS

2005 Volume 53 Issue 11 Pages 1490-1493

DOI https://doi.org/10.1248/cpb.53.1490

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Abstract

Novel sialosyl donors, 4-pentenoic acid ester of N-acetylneuraminic acids (Neu5Ac) (1a) and 4-pentenyl glycoside of Neu5Ac (1b) were successfully prepared from the corresponding per-O-acetylated 2-hydroxy and 2-chloro derivatives of Neu5Ac, respectively and applied to the synthesis of O-sialosides.

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