Chromatographic Separation of (−)-Ephedrine and (+)-Pseudoephedrine in the Traditional Chinese Medicinal Preparation Jiketing Granule

Abstract

(−)-Ephedrine (EP) and (+)-Pseudoephedrine (PEP) in Jiketing granule were separated by TLC, RP-HPLC, GC, HPLC-MS, and the chromatographic phenomenon was interpreted by the topological indices. The observed chromatographic separations of investigated components were compared. This comparison indicated that simply methods as C₁₈ RP-HPLC and GC are the more effective techniques, and more suitable than others for this preparation, for the separation of two alkaloids.