Highly Regioselective Palladium-Catalyzed Annulation Reactions of Heteroatom-Substituted Allenes for Synthesis of Condensed Heterocycles

Kiyofumi Inamoto; Akio Yamamoto; Kazutoshi Ohsawa; Kou Hiroya; Takao Sakamoto

doi:10.1248/cpb.53.1502

Notes

Highly Regioselective Palladium-Catalyzed Annulation Reactions of Heteroatom-Substituted Allenes for Synthesis of Condensed Heterocycles

Kiyofumi Inamoto, Akio Yamamoto, Kazutoshi Ohsawa, Kou Hiroya, Takao Sakamoto

著者情報

キーワード: palladium, annulation, allene, heterocycle, alkyl metal reagent

ジャーナルフリー

2005 年 53 巻 11 号 p. 1502-1507

DOI https://doi.org/10.1248/cpb.53.1502

詳細

抄録

We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.

責任著者(Corresponding author)

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