Preparation of (Cyanomethylene)tributylphosphorane: A New Mitsunobu-Type Reagent

Izumi Sakamoto; Takeshi Nishii; Fumie Ozaki; Hiroto Kaku; Masami Tanaka; Tetsuto Tsunoda

doi:10.1248/cpb.53.1508

Notes

Preparation of (Cyanomethylene)tributylphosphorane: A New Mitsunobu-Type Reagent

Izumi Sakamoto, Takeshi Nishii, Fumie Ozaki, Hiroto Kaku, Masami Tanaka, Tetsuto Tsunoda

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Keywords: Mitsunobu reaction, (cyanomethylene)tributylphosphorane (CMBP), ylide

JOURNAL FREE ACCESS

2005 Volume 53 Issue 11 Pages 1508-1509

DOI https://doi.org/10.1248/cpb.53.1508

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Abstract

(Cyanomethylene)tributylphosphorane (CMBP), which promoted the alkylation of various nucleophiles (HA) with alcohols (ROH) to give RA (Mitsunobu-type reaction), was prepared in two steps starting from chloroacetonitrile.

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