Biologically Active Glycosides from Asteroidea, 43. Isolation and Structure of a New Neuritogenic-Active Ganglioside Molecular Species from the Starfish Linckia laevigata

Masanori Inagaki; Tomofumi Miyamoto; Ryuichi Isobe; Ryuichi Higuchi

doi:10.1248/cpb.53.1551

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Biologically Active Glycosides from Asteroidea, 43. Isolation and Structure of a New Neuritogenic-Active Ganglioside Molecular Species from the Starfish Linckia laevigata

Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi

著者情報

キーワード: glycosphingolipid, ganglioside, starfish, Linckia laevigata

ジャーナルフリー

2005 年 53 巻 12 号 p. 1551-1554

DOI https://doi.org/10.1248/cpb.53.1551

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抄録

A ganglioside molecular species, LLG-5 (1), has been obtained from the water soluble lipid fraction of the CHCl₃/MeOH extract of the starfish Linckia laevigata. On the basis of chemical and spectroscopic findings, the structure of 1 has been elucidated. Negative ion FAB-MS provided important information both on the structure of the sugar moiety and on the molecular mass of the ganglioside. 1 is a new ganglioside molecular species possessing a 2→11 linked linear-type trisialosyl moiety. Moreover, 1 exhibited neuritogenic activity in rat pheochromocytoma PC-12 cells in the presence of nerve growth factor.

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