Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Three New Dimeric Benzofuran Derivatives from the Roots of Ligularia stenocephala MATSUM. et KOIDZ.
Kazuki ToyodaYasunori YaoitaMasao Kikuchi
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2005 年 53 巻 12 号 p. 1555-1558

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Three new dimeric benzofuran derivatives, ligulacephalins A (1), B (2) and C (3), were isolated from the roots of Ligularia stenocephala MATSUM. ET KOIDZ. (Compositae) together with three known compounds, 5,6-dimethoxy-2-isopropenylbenzofuran (4), euparin (5) and (R)-(−)-hydroxytremetone (6). The structures of the new compounds were determined by spectroscopic evidence. The chiral HPLC analysis demonstrated that 1—3 occurred as a racemate. The absolute configurations of each enantiomer from 1—3 were elucidated on the basis of circular dichroism (CD) data.
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© 2005 The Pharmaceutical Society of Japan
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