New Sphingolipids and a Sterol from a Lobophytum Species of the Indian Ocean

Abstract

Chemical investigation of a soft coral species of the genus Lobophytum has resulted in the isolation of three new sphingolipids—(2S,3S,4R)-2-nonadecanoylamino-octadecane-1,3,4-triol (1), (2S,3R,4E,8E)-[(2′R)-2′-hydroxyheptadecanoylamino]-4,8-octadecadiene-1,3-diol (2), 1-O-(β-D-glucopyranosyl)-(2S,3R,4E,8E)-2-[(2′R)-2′-hydroxynonadecanoylamino]-9-methyl-4,8-octadecadiene-1,3-diol (3) and a sterol—(24S)-ergost-5-en-3β,7β-diol (4) along with the known sphingolipid—(2S,3R,4E,8E)-2-hexadecanoylamino-4,8-octadecadien-1,3-diol (5) which showed cytotoxicity against human peripheral blood mononuclear cells (PBMC).