Three New Cholinesterase-Inhibiting cis-Clerodane Diterpenoids from Otostegia limbata

Viqar Uddin Ahmad; Afsar Khan; Umar Farooq; Farzana Kousar; Saleha Suleman Khan; Sarfraz Ahmad Nawaz; Muhammad Athar Abbasi; Muhammad Iqbal Choudhary

doi:10.1248/cpb.53.378

Regular Articles

Three New Cholinesterase-Inhibiting cis-Clerodane Diterpenoids from Otostegia limbata

Viqar Uddin Ahmad, Afsar Khan, Umar Farooq, Farzana Kousar, Saleha Suleman Khan, Sarfraz Ahmad Nawaz, Muhammad Athar Abbasi, Muhammad Iqbal Choudhary

著者情報

Viqar Uddin Ahmad
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Afsar Khan
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Umar Farooq
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Farzana Kousar
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Saleha Suleman Khan
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Sarfraz Ahmad Nawaz
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Muhammad Athar Abbasi
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi
Muhammad Iqbal Choudhary
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi

キーワード: Lamiaceae, Otostegia limbata, clerodane diterpenoid, cholinesterase inhibitory assay

ジャーナルフリー

2005 年 53 巻 4 号 p. 378-381

DOI https://doi.org/10.1248/cpb.53.378

詳細

抄録

Three new tricyclic cis-clerodane type diterpenoids trivially named as limbatolide A (1), limbatolide B (2) and limbatolide C (3) have been isolated from the roots of Otostegia limbata along with two known compounds; oleanic acid and β-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D) NMR techniques. Compounds 1—3 displayed inhibitory potential in a concentration-dependent manner against acetylcholinesterase (AChE; EC 3.1.1.7) and butyrylcholinesterase (BChE; EC 3.1.1.8) enzymes, respectively.

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