2005 年 53 巻 4 号 p. 393-397
A total synthesis of a new furo[3,2-h]isoquinoline alkaloid TMC120-B (2), isolated from Aspergillus ustus together with two related compounds, has been completed in sixteen steps. The key step is the synthesis of the appropriate 3,7,8-trisubstituted isoquinoline framework (23) based on a thermal electrocyclic reaction of the 1-aza 6π-electron system involving the benzene double bond. In addition, the microwave assisted electrocyclic reaction of this system was newly performed.