An Easy Access to 7-Methyl-2-naphthalenecarbonitrile

Hiroyuki Koshio; Tsukasa Ishihara; Hiroyoshi Yamada; Fukushi Hirayama; Yuzo Matsumoto; Isao Yanagisawa

doi:10.1248/cpb.53.448

Notes

An Easy Access to 7-Methyl-2-naphthalenecarbonitrile

Hiroyuki Koshio, Tsukasa Ishihara, Hiroyoshi Yamada, Fukushi Hirayama, Yuzo Matsumoto, Isao Yanagisawa

著者情報

キーワード: inhibitor, bicyclic compound, nitrile, condensation, cyclization

ジャーナルフリー

2005 年 53 巻 4 号 p. 448-450

DOI https://doi.org/10.1248/cpb.53.448

詳細

抄録

A practical and cost-effective procedure has been developed for the synthesis of 7-methyl-2-naphthalenecarbonitrile, the precursor of the anticoagulant agents YM-60828 or YM-96765. This new route generates the key intermediate in only two steps from readily available 3-cyanopropionaldehyde dimethyl acetal and m-tolualdehyde, without requiring chromatographic purification. The synthesis involves condensation of the cyano derivative with the aldehyde and subsequent cyclodehydration.

責任著者(Corresponding author)

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