Concise Synthesis of dl-Febrifugine

Yasuo Takeuchi; Miyo Oshige; Kumiko Azuma; Hitoshi Abe; Takashi Harayama

doi:10.1248/cpb.53.868

Communications to the Editor

Concise Synthesis of dl-Febrifugine

Yasuo Takeuchi, Miyo Oshige, Kumiko Azuma, Hitoshi Abe, Takashi Harayama

著者情報

キーワード: total synthesis, stereoselective Michael reaction, Wittig reaction, febrifugine, antimalarial activity

ジャーナルフリー

2005 年 53 巻 7 号 p. 868-869

DOI https://doi.org/10.1248/cpb.53.868

詳細

抄録

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）