Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity

Yutaka Aoyagi; Yoshinao Takahashi; Haruhiko Fukaya; Koichi Takeya; Ritsuo Aiyama; Takeshi Matsuzaki; Shusuke Hashimoto; Teruo Kurihara

doi:10.1248/cpb.54.1602

Notes

Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity

Yutaka Aoyagi, Yoshinao Takahashi, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto, Teruo Kurihara

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Keywords: semisynthesis, isetexane diterpenoid, cytotoxic, microwave, structure activity relationships (SAR)

JOURNAL FREE ACCESS

2006 Volume 54 Issue 11 Pages 1602-1604

DOI https://doi.org/10.1248/cpb.54.1602

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Abstract

Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.

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