Synthesis and Peptidyl-Prolyl Isomerase Inhibitory Activity of Quinoxalines as Ligands of Cyclophilin A

Feng Wang; Jing Chen; Xuejun Liu; Xu Shen; Xuchang He; Hualiang Jiang; Donglu Bai

doi:10.1248/cpb.54.372

Notes

Synthesis and Peptidyl-Prolyl Isomerase Inhibitory Activity of Quinoxalines as Ligands of Cyclophilin A

Feng Wang, Jing Chen, Xuejun Liu, Xu Shen, Xuchang He, Hualiang Jiang, Donglu Bai

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Keywords: quinoxaline, peptidyl-prolyl isomerase inhibitory activity, cyclophilin A, ligand

JOURNAL FREE ACCESS

2006 Volume 54 Issue 3 Pages 372-376

DOI https://doi.org/10.1248/cpb.54.372

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Abstract

In search of small molecule compounds as the ligands of cyclophilin A, a series of quinoxalines were prepared, and their K_d values of cyclophilin A and IC₅₀ values for peptidyl-prolyl isomerase activity of cyclophilin A were tested. The results suggest that some quinoxalines are promising ligands of cyclophilin A.

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