Alleviative effect of sodium butyrate on high-fructose-diet-induced hepatic accumulation of triacylglycerol is associated with reduced expression levels of fructolytic and fatty acid synthetic enzymes in rats

Abstract

Sodium butyrate (NaB) intake reduces high-sucrose diet-induced hepatic expression of genes and proteins related to fatty acid synthesis and the accumulation of triacylglycerols (TAGs) in rats. In this study, we examined the effects of NaB intake on the hepatic accumulation of TAGs and the expression of genes and proteins related to lipid metabolism, including fructolysis induced by excessive ingestion of fructose, a more potent inducer of lipogenesis than sucrose. Dietary supplementation with 5 % NaB decreased the high-fructose-induced hepatic levels of TAG and the expression levels of genes and proteins related to fructolysis and fatty acid synthesis, but not those related to β-oxidation. These results suggest that NaB intake alleviates high-fructose-induced non-alcoholic fatty liver disease by suppressing a wide range of pathways, including those from fructolysis to fatty acid synthesis.