Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Triterpenoids from Hippophae rhamnoides L. and Their Nitric Oxide Production-Inhibitory and DPPH Radical-Scavenging Activities
Zhi-Gang YangHe-Ran LiLi-Yan WangYong-Hai LiShun-Guang LuXiu-Feng WenJue WangAkihiro DaikonyaSusumu Kitanaka
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2007 Volume 55 Issue 1 Pages 15-18


In our investigation on the chemical constituents of Hippophae rhamnoides L., the chloroform-soluble fraction of the 80% acetone extract of branch bark was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ-activated murine macrophage-like cell line, RAW 264.7 cells. Two new triterpenoids, 2-O-trans-p-coumaroyl maslinic acid (1) and 2-O-caffeoyl maslinic acid (2), and three known triterpenoids, oleanolic acid (3), 3-O-trans-p-coumaroyl oleanolic acid (4), and 3-O-caffeoyl oleanolic acid (5), and 6-methoxy-2H-1-benzopyran (6) and β-sitosterol (7) were isolated from the branch bark extract. Their inhibitory activities on the production of NO in RAW 264.7 cells and radical-scavenging activities were examined.

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© 2007 The Pharmaceutical Society of Japan
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