Medicinal Flowers. XII.1) New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from Borassus flabellifer

Masayuki Yoshikawa; Fengming Xu; Toshio Morikawa; Yutana Pongpiriyadacha; Seikou Nakamura; Yasunobu Asao; Akira Kumahara; Hisashi Matsuda

doi:10.1248/cpb.55.308

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Medicinal Flowers. XII.¹⁾ New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from Borassus flabellifer

Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Yutana Pongpiriyadacha, Seikou Nakamura, Yasunobu Asao, Akira Kumahara, Hisashi Matsuda

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Keywords: Borassus flabellifer, antidiabetogenic activity, borassoside, 22β-O-spirostane-type steroid saponin, dioscin

JOURNAL FREE ACCESS

2007 Volume 55 Issue 2 Pages 308-316

DOI https://doi.org/10.1248/cpb.55.308

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Abstract

The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A—F (1—6), were isolated together with 23 known constituents. The structures of borassosides (1—6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.

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