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Volume 55, Issue 2
Displaying 1-25 of 25 articles from this issue
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Review
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Biswanath Dinda, Sudhan Debnath, Yoshihiro Harigaya2007 Volume 55 Issue 2 Pages 159-222
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSA compilation of new naturally occurring iridoid glycosides, iridoid aglycones, iridoid derivatives and bis-iridoids reported during 1994—2005 is provided with available physical and spectral data: mp, [α]D, UV, IR, 1H- and 13C-NMR as well as natural source with family and references. 418 compounds with 202 references are cited.View full abstractDownload PDF (2663K)
Regular Articles
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Mauro Vieira de Almeida, Francisco Martins Teixeira, Marcus Vinicius N ...2007 Volume 55 Issue 2 Pages 223-226
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSFourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An in vitro investigation of the compounds as inhibitors of the TNF-α production was performed. The inhibition was higher for compounds bearing amino and nitro groups and was modulated by increasing the size of the spacers between the phthalimide groups.View full abstractDownload PDF (119K) -
Mohamed Mohmoud Hefnawy, Maha Abd-Alrahman Sultan, Mona Mohamed Al-She ...2007 Volume 55 Issue 2 Pages 227-230
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSA sensitive, enantioselective, high-performance liquid chromatographic (HPLC) method was developed and validated to determine S-(−)- and R-(+)-bisoprolol in human plasma. Baseline resolution was achieved using the teicoplanin macrocyclic antibiotic chiral stationary phase (CSP) known as Chirobiotic T with a polar ionic mobile phase (PIM) consisting of methanol–glacial acetic acid–triethylamine (100 : 0.02 : 0.025, v/v/v) at a flow rate of 1.5 ml/min and fluorescence detection set at 275 nm for excitation and 305 nm for emission. All analyses with S-(−)-atenolol as the internal standard were conducted at ambient temperature. The assay involved the use of a solid-phase extraction procedure for human plasma samples prior to HPLC analysis. The C18 cartridge gave good recovery rates for both enantiomers without any interference. The method was validated over the range of 20—200 ng/ml for each enantiomer concentration. Recovery rates for S-(−)- and R-(+)-bisoprolol enantiomers were in the range of 95—102%. The method proved to be precise (within-run precision expressed as % RSD ranged from 1.0—6.2% and between-run precision ranged from 0.9—6.7%) and accurate (within-run accuracies expressed as percentage error ranged from 0.2—4.8% and between-run accuracies ranged from 0.3—1.7%). The limit of quantitation and limit of detection for each enantiomer in human plasma were 20 and 5 ng/ml, respectively.View full abstractDownload PDF (95K) -
Hongshan Yu, Chunzhi Zhang, Mingchun Lu, Fang Sun, Yaoyao Fu, Fengxie ...2007 Volume 55 Issue 2 Pages 231-235
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSIn this paper, the new type ginsenosidase which hydrolyzing multi-glycosides of ginsenoside, named ginsenoside type I from Aspergillus sp.g48p strain was isolated, characterized and generally described. The enzyme molecular weight was about 80 kDa. Ginsenosidase type I can hydrolyze different glycoside of protopanaxadiol type ginsenosides (PPD); i.e., can hydrolyze the 3(carbon)-O-β-glucoside of Rb1, Rb2, Rb3, Rc, Rd; can hydrolyze 20(carbon)-O-β-glucoside of Rb1, 20-O-β-xyloside of Rb3, 20-O-α-arabinoside(p) of Rb2 and 20-O-α-arabinoside(f) of Rc to produce mainly F2, compound-K (C-K) and small Rh2, but can not hydrolyze the glycosides of protopanaxatriol type ginsenoside (PPT) such as Re, Rf, Rg1. So, when the ginsenosidase type I hydrolyzed ginsenosides, the enzyme selected ginsenoside-aglycone type, can hydrolyze different glycosides of PPD type ginsenoside; however no selected glycoside type, can hydrolyze multi-glycosides of PPD type ginsenosides. These properties were novel properties, and differentiated with the other previously described glycosidases.View full abstractDownload PDF (247K) -
Sunil Kumar Reddy Aaramadaka, Mrinal kanthi Guha, Ganesh Prabhu, Suvar ...2007 Volume 55 Issue 2 Pages 236-240
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSUrea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity.View full abstractDownload PDF (142K) -
Bharat Ganeshbhai Chaudhari, Natvarlal Manilal Patel, Paresh Bhagvatip ...2007 Volume 55 Issue 2 Pages 241-246
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSThe study describes development and subsequent validation of a stability indicating reverse-phase HPLC method for the simultaneous estimation of atorvastatin (ATV), and amlodipine (AML) from their combination drug product. The proposed RP-HPLC method utilizes a Lichrospher® 100 C18, 5 μm, 250 mm×4.0 mm i.d. column, at ambient temperature, optimum mobile phase consisted of acetonitrile and 50 mM potassium dihdrogen phosphate buffer (60 : 40, v/v), apparent pH adjusted to 3±0.1 with 10% phosphoric acid solution, effluent flow rate monitored at 1.0 ml/min, and UV detection at 254 nm. ATV, AML, and their combination drug product were exposed to thermal, photolytic, hydrolytic, and oxidative stress conditions, and the stressed samples were analyzed by proposed method. The method was applied for the in vitro dissolution of marketed combination drug products. The described method was linear over the range of 1—90 μg/ml and 1—80 μg/ml for ATV and AML, respectively. The mean recoveries were 99.76 and 98.12% for ATV and AML, respectively. The intermediate precision data obtained under different experimental setup, the calculated value of coefficient of variation (CV, %) was found to be less than critical value. The limit of detection for ATV and AML were found to be 0.4 and 0.6 μg/ml, respectively and the limit of quantification was 1.0 μg/ml for both drugs. The average percentage drug release was found to be more than 70% within 30 min for both drugs. Chromatographic peak purity data of ATV and AML indicated no co-eluting peaks with the main peaks of drugs which demonstrated the specificity of assay method for their estimation in presence of degradation products. The proposed method can be useful in the quality control and in vitro dissolution of combination drug products.View full abstractDownload PDF (716K) -
Shoujiro Ogawa, Keiji Hosoi, Noriaki Ikeda, Mitsuko Makino, Yasuo Fuji ...2007 Volume 55 Issue 2 Pages 247-250
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSOxyfunctionalization of the bioactive terpenoids, ursolic acid acetate (1), oleanolic acid acetate (5), lupeol acetate (12), and kaurenic acid (17), with dimethyldioxirane (DMDO) was investigated. Treatment of the terpenoids with DMDO under mild conditions afforded a variety of oxidation and oxydegradation products to yield naturally occurring and/or novel compounds in one step. After chromatographic separation, the structures of the individual isolated products were determined using spectroscopic methods including several homonuclear (1H–1H) and heteronuclear (1H–13C) shift-correlated 2D-NMR techniques. The inhibitory activity of the terpenoid derivatives against α-glucosidase was investigated and compounds 1, 3, 7, and 9 were found to exhibit potent activity.View full abstractDownload PDF (178K) -
Effat Souri, Hassan Jalalizadeh, Abbas Kebriaee-Zadeh, Bettina Zadehva ...2007 Volume 55 Issue 2 Pages 251-254
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSIn this study, a high performance liquid chromatography method with UV detection was developed for determination of orlistat. The chromatographic system consisted of a Nova-Pack C18 column, an isocratic mobile phase of phosphoric acid 0.1%–acetonitrile (10 : 90, v/v) and UV detection at 205 nm. Orlistat was eluted at about 6 min with no interfering peak from excipients used for preparation of dosage form. The method was linear over the range of 10—160 μg/ml orlistat (r2>0.9999). The within-day and between-day precision values were also in the range of 0.10—0.59%. The appropriate dissolution conditions were also determined and applied to evaluate the dissolution profile of orlistat capsules. Optimal conditions were 1000 ml of 3% SLS in water as dissolution medium and paddle at 100 rotation per minute. The proposed method was applied successfully to the determination of orlistat content in capsules and in vitro dissolution studies.View full abstractDownload PDF (153K) -
Katsuyuki Aoki, Tatsuhiro Obata, Yosuke Yamazaki, Yoshikazu Mori, Hiro ...2007 Volume 55 Issue 2 Pages 255-267
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSWe found previously that 7-[3-(cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one (7d-6) has considerable potency as a PDGF inhibitor. This compound showed potent inhibitory activity in a PDGF-induced CPA (Cell Proliferation Assay) and APA (Auto-Phosphorylation Assay) (IC50=0.05 μmol/l in CPA, 0.03 μmol/l in APA). Therefore, we tried to develop a novel and effective PDGF-βR inhibitor by optimizing a series of its derivatives. We found that trifluoroacetic acid (TFA)-catalyzed coupling of pyrrolo[2,3-b]pyridines with quinoxalin-2-ones proceeded efficiently under mild oxidation condition with manganese(IV) oxide (MnO2) in situ, so this method was applied to prepare a series of derivatives. Results of in vitro screening of newly synthesized derivatives identified compound 7d-9 as having potent (IC50=0.014 μmol/l in CPA, 0.007 μmol/l in APA) and selective [IC50 values against vascular endothelial growth factor receptor 2 (VEGFR2, kinase domain region, KDR), epidermal growth factor receptor (EGFR), c-Met (hepatocyte growth factor receptor) and insulin growth factor I receptor (IGF-IR)/IC50 against PDGFR were each >1000] inhibitory activity. Moreover, in this series of derivatives, 7b-2 showed potent inhibitory activity toward both PDGF- and VEGF-induced signaling (PDGFR: IC50=0.004 μmol/l in CPA, 0.0008 μmol/l in APA, KDR: IC50=0.008 μmol/l in APA). Herein we report a new and convenient synthetic method for this series of derivatives and its SAR study.View full abstractDownload PDF (358K) -
Shoko Taniguchi, Kayo Kuroda, Kou-ichi Doi, Masahiro Tanabe, Takashi S ...2007 Volume 55 Issue 2 Pages 268-272
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSGambir, the aqueous extract from Uncaria gambir (Rubiaceae), has been used as an astringent medicine in Asian countries. Investigation of the constituents in the extract led to the isolation of four chalcane-flavan dimers, gambiriin A1 (6), A2 (7), B1 (8), and B2 (9), in addition to (+)-catechin (1), (+)-epicatechin (2), and dimeric proanthocyanidins, procyanidin B1 (3), procyanidin B3 (4), and gambiriin C (5). The spectroscopic and chemical data obtained in the present study indicated that their previously proposed structures 6a, 7a, 8a, and 9a should be revised to 6, 7, 8, and 9, respectively.View full abstractDownload PDF (233K) -
Akihito Yokosuka, and Yoshihiro Mimaki2007 Volume 55 Issue 2 Pages 273-279
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSFive new glycosides, which are classified into two bisdesmosidic pseudofurostanol glycosides (1, 2), two new ergostanol glycosides (3, 4), and a new phenolic glycoside (5), were isolated from the rhizomes of Tacca chantrieri. The structures of 1—5 were determined on the basis of extensive spectroscopic analysis, including that of two-dimensional (2D) NMR data, as well as hydrolytic cleavage followed by spectroscopic and chromatographic analyses.View full abstractDownload PDF (195K) -
Ya-Ching Shen, Yu-Chi Lin, Atallah F. Ahmed, Yuan-Bin Cheng, Chia-Chin ...2007 Volume 55 Issue 2 Pages 280-283
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSFour new nona-oxygenated C18 dibenzocyclooctadiene lignans, kadsuphilins C—F (1—4), were isolated from the EtOAc soluble portion of the alcoholic extract of the aerial parts of Kadsura philippinensis. The structures of 1—4 were elucidated on the basis of extensive spectroscopic analyses, including 2D NMR (HMQC, HMBC, and NOESY) experiments, comparison of the spectral data with those of the related metabolites. The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1—4 also have been evaluated.View full abstractDownload PDF (128K) -
Hsu-Shan Huang, In-Been Chen, Kuo-Feng Huang, Wei-Chih Lu, Fu-Ying Shi ...2007 Volume 55 Issue 2 Pages 284-292
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSTelomerase is the enzymatic activity that maintains the ends of eukaryotic chromosomes. Telomerase activity is detected in most tumor cells whereas it is low or undetectable in most normal somatic cells. Expression of the telomerase catalytic component, the human telomerase reverse transcriptase (hTERT), is believed to be controlled primarily at the level of transcription. Because of this selective expression property of telomerase, it has been touted as a specific target for antitumor chemotherapeutics. However, a concern for the applicability of telomerase inhibitors is that they require a long lag time for telomeres to be shortened to critical length before cancer cells stop proliferating. Here we investigate telomerase inhibitory, cytotoxicity and the hTERT repressing effects on a number of synthesized 2,6-diamidoanthraquinones and 1,5-diamidoanthraquinones as compared to their disubstituted homologues. We found that several of the 1,5-diamidoanthraquinones and 2,6-diamidoanthraquinones inhibited telomerase activity effectively with IC50 at the sub-micro to micro molar range and caused acute cytotoxicity to cancer cells with EC50 similar or better than that of mitoxantrone. Particularly, 2,6-diamidoanthraquinone with 2-ethylaminoacetamido side chains 33, even though not affecting cell proliferation, showed to be endowed with a strong telomerase effect, probably related to a marked stabilization of the G-quadruplex-binding structure. The results suggested that these compounds caused multiple effects to cancer cells. More significantly, they overcome the long lag period problem of classical telomerase inhibitors that they are also potent cytotoxic agents. These results greatly expand the potential of tricyclic anthraquinone pharmacophore in preventive and/or curative therapy.View full abstractDownload PDF (315K) -
Toshio Morikawa, Seikou Nakamura, Yasuyo Kato, Osamu Muraoka, Hisashi ...2007 Volume 55 Issue 2 Pages 293-298
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSNew triterpene saponins, foliatheasaponins I—V, were isolated from the methanolic extract of Tencha [the leaves of Camellia sinensis (L.) O. KUNTZE (Theaceae)]. The chemical structures of these new saponins were elucidated on the basis of chemical and physicochemical evidence. Among the new saponins, foliatheasaponins II and III, were found to inhibit release of β-hexosaminidase, as a marker of antigen-induced degranulation, in RBL-2H3 cells.View full abstractDownload PDF (188K) -
Shinobu Sakai, Eri Otake, Toshihiko Toida, Yukihiro Goda2007 Volume 55 Issue 2 Pages 299-303
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSTwelve “health foods” products containing chondroitin sulfate (CS) were purchased from the Japanese market and the origin of the CS was investigated by conducting disaccharide compositional analysis after enzymatic depolymerization and by 1H-NMR spectroscopy. Nine of the 12 products had labels indicating that the origin of the CS was shark cartilage. However, two of them were found to contain mammalian CS. Next, we compared the ratio of the sulfate group to the galactosamine residue after the acid hydrolysis of CS. The results suggest that all of the CS from sharks had a ratio of more than 1.0, while the CS from mammals had a ratio of less than 1.0. Since this comparative analysis does not require expensive purified enzyme, it would be an economical way to identify the origin of CS in “health foods.” Being able to determine the origin of the ingredients in natural products is very important for ensuring their quality, safety, and efficacy. Therefore, we think that regulatory requirements for accurately indicating the origin of “health foods” and effective enforcement of these requirements are needed.View full abstractDownload PDF (141K) -
Taridaporn Bunyapaiboonsri, Seangaroon Yoiprommarat, Kamolphan Interey ...2007 Volume 55 Issue 2 Pages 304-307
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSTwo novel diphenyl ether glycosides and a new diphenyl ether, cordyol A—C (1—3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 μg/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 μg/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 μg/ml.View full abstractDownload PDF (102K) -
Masayuki Yoshikawa, Fengming Xu, Toshio Morikawa, Yutana Pongpiriyadac ...2007 Volume 55 Issue 2 Pages 308-316
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSThe methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A—F (1—6), were isolated together with 23 known constituents. The structures of borassosides (1—6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.View full abstractDownload PDF (442K) -
Fumihiko Saitoh, Hidemitsu Nishida, Takafumi Mukaihira, Naoto Kosuga, ...2007 Volume 55 Issue 2 Pages 317-323
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSIn the course of development of factor Xa (FXa) inhibitors, we have found unique compounds containing an N,O- and an N,N-spiro acetal structure. It appeared that the difference in overall conformation due to the N,X-spiro acetal structure might be important for FXa inhibitory activity. Therefore, other N,X-spiro acetal structures, an N,S- and an N,SO2-spiro acetal, were developed as analogues of the N,X-spiro acetal structure. Compound 7b (N,S-spiro acetal structure) was found to have the strongest activity in these series of N,X-spiro acetal compounds, which had ever been synthesized.4,5)View full abstractDownload PDF (190K)
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Guoqing Zhang, Zhanying Hong, Yifeng Chai, Zhenyu Zhu, Yunlong Song, C ...2007 Volume 55 Issue 2 Pages 324-327
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSThe purpose of this paper was to study the chiral recognition mechanism of enantioseparation of adrenaline and its analogues using capillary electrophoresis. The enantiomeric separation of adrenaline and its analogues has been developed using beta-cyclodextrins as the chiral selectors. All the tested compounds were separated under the same experimental conditions to study the chiral recognition mechanisms, using a low-pH buffer (50 mM Tris buffer at pH 2.5). By means of molecular docking the inclusion course between beta-cyclodextrins and enantiomers was investigated and thus the interaction energy was obtained by molecular mechanics calculations. The results suggest that the difference in interaction energy for the side chain part is most likely responsible for enantiomeric separation.View full abstractDownload PDF (274K) -
Yasushi Igarashi, Erika Yanagisawa, Toshihiro Ohshima, Shuichi Takeda, ...2007 Volume 55 Issue 2 Pages 328-333
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSA series of carbamates of the phenolic compound 1 were prepared and evaluated in vivo as its prodrug. Each carbamate was orally administered to rats, and plasma concentrations of the parent compound 1 were measured with the passage of time. We judged which carbamate was suitable for the prodrug of 1 from both the AUC value of 1 and absence of the carbamate in plasma. The AUC value of 1 after oral administration of 2b was approximately 40-fold higher than that for an administration of 1, and the bioconversion from 2b to 1 was excellent. As a whole, di-substituted carbamates resulted in higher plasma concentrations of 1 than did mono-substituted ones. However di-substituted carbamates were almost always detected in plasma. As a result, we found that the ethycarbamoyl derivative 2b demonstrates the best prodrug property in this series.View full abstractDownload PDF (210K) -
Tsutomu Nakanishi, Yuka Inatomi, Hiroko Murata, Syun-suke Ishida, Yuri ...2007 Volume 55 Issue 2 Pages 334-336
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSA new ursane-type triterpene, named as cheiranthic acid (1), was isolated from the MeOH extract of whole plants of Oenothera cheiranthifolia (Onagraceae) along with an isomeric pair of known oleanane- and ursane-type triterpenes (arjunolic acid and asiatic acid) and three flavonol glucuronide analogues (quercetin 3-O-glucuronide, its n-butyl ester, and myricetin 3-O-glucuronide). Their structures were elucidated based on spectroscopic evidence.View full abstractDownload PDF (93K) -
Taro Higano, Minpei Kuroda, Hiroshi Sakagami, Yoshihiro Mimaki2007 Volume 55 Issue 2 Pages 337-339
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSThe rhizomes of Convallaria majalis have been analyzed for their steroidal glycoside constituents, resulting in the isolation of a new 5β-spirostanol triglycoside, named convallasaponin A, along with two known cardenolide glycosides and a known cholestane glycoside. The structure of convallasaponin A was determined on the basis of extensive spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage. The cardenolide glycosides showed tumor specific cytotoxic activity.View full abstractDownload PDF (96K) -
Yang-Gyun Kim, Khac-Minh Thai, Jieun Song, Kyeong Kyu Kim, Hyun-Ju Par ...2007 Volume 55 Issue 2 Pages 340-342
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSWe describe the first discovery of small molecules that bind to the Z-DNA binding domain of human ADAR1 (Adenosine Deaminase Acting on RNA 1) by structure-based virtual screening of chemical database. These molecules bind to Z-DNA binding domain to inhibit the interaction with the Z-DNA. Many viruses have Z-DNA binding proteins, which are structurally similar to Z-DNA binding domain of human ADAR1, and the ability of Z-DNA binding protein to bind the Z-DNA is essential for their pathogenicity. Therefore, the molecules identified in this study may serve as novel leads for the design of agents that inhibit biological functions of those pathogenic viruses.View full abstractDownload PDF (821K) -
Junko Takashima, Yoshitaka Ikeda, Kanki Komiyama, Masahiko Hayashi, Ak ...2007 Volume 55 Issue 2 Pages 343-345
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSA new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.View full abstractDownload PDF (93K) -
Hirotsugu Yamauchi, Rie Kakuda, Yasunori Yaoita, Koichi Machida, Masao ...2007 Volume 55 Issue 2 Pages 346-347
Published: 2007
Released on J-STAGE: February 01, 2007
JOURNAL FREE ACCESSTwo new glycosides, 7S,7′S,8R,8′R-icariol A2-9-O-β-D-glucopyranoside (1) and 4-allyl-2-hydroxyphenyl 1-O-β-D-apiosyl-(1→6)-β-D-glucopyranoside (2), were isolated from the dried whole plants of Glechoma hederacea L. (Labiatae) together with four known compounds, cistanoside E (3), dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (4), apigenin 7-O-β-D-glucuronopyranoside (5) and luteolin 7-O-β-D-glucopyranoside (6). The structures of the new compounds were elucidated on the basis of chemical and spectral analysis.View full abstractDownload PDF (91K)
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