Secondary Metabolites from Andrographis paniculata

Wenkui Li; Xudong Xu; Hongjie Zhang; Cuiying Ma; Harry Fong; Richard van Breemen; John Fitzloff

doi:10.1248/cpb.55.455

Notes

Secondary Metabolites from Andrographis paniculata

Wenkui Li, Xudong Xu, Hongjie Zhang, Cuiying Ma, Harry Fong, Richard van Breemen, John Fitzloff

Author information

Wenkui Li
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Functional Food for Health (FFH) Core Analytical Laboratory, College of Pharmacy, University of Illinois at Chicago
Xudong Xu
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Functional Food for Health (FFH) Core Analytical Laboratory, College of Pharmacy, University of Illinois at Chicago
Hongjie Zhang
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Cuiying Ma
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Harry Fong
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Richard van Breemen
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
John Fitzloff
Department of Medicinal Chemistry and Pharmacognosy (m/c 781), University of Illinois at Chicago
Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS, m/c 877), University of Illinois at Chicago
Functional Food for Health (FFH) Core Analytical Laboratory, College of Pharmacy, University of Illinois at Chicago

Keywords: Andrographis paniculata, secondary metabolite, flavonoid, diterpenoid, LC-MS/MS, cytotoxicity

JOURNAL FREE ACCESS

2007 Volume 55 Issue 3 Pages 455-458

DOI https://doi.org/10.1248/cpb.55.455

Details

Abstract

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy-flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED₅₀ values of 6.5 and 5.1 μg/ml, respectively.

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