Synthesis, Spectroscopic and Cytotoxic Studies of Biologically Active New Schiff Bases Derived from p-Nitrobenzaldehyde

Amjid Iqbal; Hamid Latif Siddiqui; Chaudhary Muhammad Ashraf; Mujahid Hussain Bukhari; Chaudhary Muhammad Akram

doi:10.1248/cpb.55.1070

Notes

Synthesis, Spectroscopic and Cytotoxic Studies of Biologically Active New Schiff Bases Derived from p-Nitrobenzaldehyde

Amjid Iqbal, Hamid Latif Siddiqui, Chaudhary Muhammad Ashraf, Mujahid Hussain Bukhari, Chaudhary Muhammad Akram

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Keywords: p-nitrobenzadehyde, primary amine, unusual aldehyde reduction, biological activity

JOURNAL FREE ACCESS

2007 Volume 55 Issue 7 Pages 1070-1072

DOI https://doi.org/10.1248/cpb.55.1070

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Abstract

Thirteen new Schiff bases derived from p-nitrobenzaldehyde were synthesized by condensation with the appropriate amines. An unusual reduction of the p-nitrobenzaldehyde to the corresponding alcohol was also observed in one of the reactions. The structures of the compounds were identified using spectroscopic techniques. Cytotoxicity for the titled compounds was studied against Brine Shrimp, used as the test animal.

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