Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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A New Leishmanicidal Saponin from Brunfelsia grandiflora
Hiroyuki FuchinoSetsuko SekitaKanami MoriNobuo KawaharaMotoyoshi SatakeFumiyuki Kiuchi
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2008 Volume 56 Issue 1 Pages 93-96

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Abstract

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of 1 was determined by spectroscopic analysis and chemical reaction to be 26-O-β-D-glucopyranosyl 22α-methoxyfurost-3β,26-diol 3-O-β-D-xylopyranosyl(1→3)-{β-D-glucopyranosyl(1→2)}-β-D-glucopyranosyl(1→4)-β-D-glucopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

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© 2008 The Pharmaceutical Society of Japan
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