Spectroscopic, Thermal and Biological Studies of the Coordination Compounds of Sulfasalazine Drug: Mn(II), Hg(II), Cr(III), ZrO(II), VO(II) and Y(III) Transition Metal Complexes

Abstract

The complexations of sulfasalazine (H₃Suz) with some of transition metals have been investigated. Three types of complexes, [Mn(HSuz)⁻²(H₂O)₄] · 2H₂O, [M(HSuz)⁻²(H₂O)₂] · xH₂O (M=Hg(II), ZrO(II) and VO(II), x=4, 8 and 6, respectively) and [M(HSuz)⁻²(Cl)(H₂O)₃] · xH₂O (M=Cr(III) and Y(III), x=5 and 6, respectively) were obtained and characterized by physicochemical and spectroscopic methods. The IR spectra of the complexes suggest that the H₃Suz behaves as a bidentate ligand. The thermal decomposition of the complexes as well as thermodynamic parameters (ΔE*, ΔH*, ΔS* and ΔG*) were estimated using Coats–Redfern and Horowitz–Metzger equations. In vitro antimicrobial activities of the H₃Suz and the complexes were tested.